systems biology

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Seattle Biomed pioneering ‘rational’ approach to vaccines | 

Early anti-vaccine hysteria. Cartoon of Edward Jenner administering cowpox vaccine to frightened young women, and cows emerging from different parts of people's bodies.
Early anti-vaccine hysteria. Cartoon of Edward Jenner administering cowpox vaccine to frightened young women, and cows emerging from different parts of people’s bodies.
Wikipedia, James Gilray

Vaccines are widely, legitimately, hailed as one of medicine’s most powerful weapons in the fight against infectious disease. Millions of lives are saved, deaths prevented, every year using this simple tool that can cost as little as a handful of pennies.

Holy bang for the buck, batman!

So it’s unfortunate we know so little about how vaccines actually work. Not knowing has spawned a persistent anti-vaccine movement by those who fear, based on little hard evidence, the potential for harm caused by tweaking our immune system.

But not knowing is also causing some problems for the biomedical community.

“I don’t see how we’re going to ever develop effective vaccines against AIDS, TB or malaria without first gaining a lot more insight into how the immune system works – and how vaccines promote immunity,” said Alan Aderem, president of Seattle Biomed, a research organization that has been working on matters of global health since Bill Gates was a teenager. Continue reading

Using supercomputers to find vaccines against malaria, AIDS and TB | 

Flickr, ghinson

Scientists in Seattle hope to pioneer a more “rational” approach to vaccine development, exploiting powerful computers to better identify immune system targets and reduce the huge burden (and cost) of clinical testing.

“I intend to focus first on malaria vaccines,” said Alan Aderem, an internationally recognized immunologist who will soon be taking the helm of Seattle BioMed. Aderem co-authored a paper in this week’s edition of Nature in which he outlines a new strategy aimed at discovering vaccines against HIV, TB and malaria.

Arguably, the ways in which researchers test and develop vaccines against disease today haven’t changed that much since the 18-century British physician Edward Jenner injected a young man with cowpox to see if it would protect him from smallpox. It did and, so the story goes, vaccines and the science of immunology were born.

Scientists certainly have more sophisticated tools and methods today, but testing a vaccine is still often a “shot in the dark” because of our incomplete understanding of how the immune response works. Continue reading